Title:- A study of standardization of Ashuddha(
Impure) & Shuddha ( Pure) Dhattura
seeds.
Dr. M. V. Agate had submitted his dissertation in
1999 Year, for the P.G. degree M.D.
Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. T. M. Nesari & research center was Tilak
Ayurved Mahavidyalaya, Pune (M.S.) India ,
& submitted to University
of Pune
Dr. Agate had done standardization
of purified & non purified Dhattura (Dhattura Metal) seeds.
Dhattura is a poisonous drug hence its
purification is necessary to reduce its toxic & adverse effects.
Dr. Agate had collected samples of
Dhattura seeds from local market, authenticated them & purified it by boiling the seeds in cow’s milk for 3 hours in
Dolayantra. Then washed with hot water & dried.
To evaluate purified (Shuddha) &
non purified (Ashuddha) seeds, Botanical, physical chemical &
standardization & toxicological study was done of both purified & non
purified seeds.
The research work was concluded as
follows-
Dhattura
seeds purified with cow’s milk showed less toxicity in comparison with non
purified seeds.
Hence textual processing of
purification of toxic drugs is necessary in standardization & clinical use
of drug.
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