Title: Hepatotropic role of
Tephrosia purpurea (Sharapunkha)
Dr.
M.M. Sathe had submitted his dissertation for the P.G. degree M. D. Dravyaguna (Ayurvedic
Pharmacology). His Guide was Dr. A.P. Deshpande &research center was Tilak
Ayurved Mahavidyalaya, Pune (M.S.) India.
Dr.
Sathe had done an experimental study of Tephrosia purpurea
(Sharapunkha)
as a hepatotropic drug. Dr. Sathe had prepared a powder of
plant from dried juice. Homogeneous solution of powder was made with the help of gum acasia. 1.5
gm of powder of the plant was added in 15 ml of distilled water& 27 mg gum
acasia was mixed.
24 healthy albino rats were selected. Four
groups were prepared, each of 6 animals.
First
group was treated with the test drug solution for 2 days. On the 3rd
day solution & paraffin together was given.
Second
group was treated with the test drug solution for 2 days. On the 3rd
day solution & ccl4 together was
given.
The
third group was treated with gum acasia for 2 days. On 3rd day
Gum-acasia & paraffin was given together.
The
forth group was treated with ccl4 diluted with paraffin only on 3rd
day.
The
3 successive days all groups were treated & on the fourth day each rat was scarified. Puncturing the heart by
needle, blood was collected in a plain bulb.
The research work was concluded as follows-
The drug was not found effective as Hepato
Protective may be due to following
reasons –
i)
Time
period may be insufficient.
ii)
Drug
dose might be come insufficient.
iii)
Sharapunkha
solution was prepared centrifuging juice of the plant & only the
precipitate was taken. Superant part was discarded.
In short Sharapunkha plant (Tephrosia purpurea) is definitely mentioned as a Hepato protective drug in Ayurveda. But
above said experimental model (CCL4 induced Hepatic Damage) may not be useful
to prove this properly.
No comments:
Post a Comment